Tags: AvrA

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  1. Engineering Therapeutic AvrA Nanoparticles With Enhanced Uptake and Intracellular Delivery With Applications in Inflammatory Bowel Disease

    29 May 2019 | Contributor(s):: Ling, Kevin

    Advisors: Julie A. Champion, Ravi Kane, Andrew Neish, Christine Payne, Mark PrausnitzThe work presented in this thesis focuses on reengineering naturally-derived, evolutionarily optimized molecules as drug delivery vehicles and therapeutics. We have identified AvrA, used by Salmonella, as an...

  2. Production and Engineering of Therapeutic Protein Nanoparticles

    11 Jan 2017 | Contributor(s):: Herrera Estrada, Lina Paola

    Advisors: Julie A Champion, Melissa Kemp, Andreas Bommarius, Christine Payne, Lakeisha TaiteProtein nanoparticles were proposed as therapeutic protein or enzyme delivery vehicles. The production of protein-enzyme nanoparticles via desolvation and self-assembly was investigated and optimized....