Microfluidic Cell Processing for Personalized and Regenerative Medicine
15 Sep 2021 | Contributor(s):: Stone, Nicholas Edwin
Advisors: Todd Sulchek, John McDonald, Alexander Alexeev, Ross Ethier, Budd TuckerCell processing lies at the heart of modern medicine. While in the past, the treatment of diseases such as cancer was based mostly on the cancer's tissue of origin and histological classification, today these...
Studies in Using Gold Nanoparticles in Treating Cancer and Inhibiting Metastasis
20 May 2020 | Contributor(s):: Wu, Yue
Advisors: Mostafa A. El-Sayed, Ingeborg Schmidt-Krey, Ronghu Wu, Robert Dickson, Zhong Lin WangBased on statistics from the World Health Organization, cancer is among the top killers in the world. Metastasis, which is the process of cancer cells leaving their primary location and forming...
Adhesion Signature Based Enrichment of Tumor Initiating Cells
21 Aug 2019 | Contributor(s):: Cermeno, Efrain
Advisors: Andres J Garcia, Susan N Thomas, Emina H Huang, Hang Lu, Todd C McDevittIn spite of major therapeutic advances, cancer relapse and low rates of patient response to cancer therapeutics persist. This failure is due in part to a small subpopulation of tumor initiating cells (TICs) with...
Investigation of Stiffness as a Biomarker in Ovarian Cancer Cells
13 Jan 2014 | Contributor(s):: Xu, Wenwei
Advisors: Todd Sulchek, Alexander Alexeev, Cheng Zhu, Wilbur Lam, John McDonaldIn this dissertation, we developed cell stiffness as a biomarker in ovarian cancer for the purpose of grading metastatic potential. By measuring single cell stiffness with atomic force microscopy and quantifying in...
Chemistry, Photophysics, and Biomedical Applications of Gold Nanotechnologies
03 Jun 2012 | Contributor(s):: Dreaden, Erik Christopher
Advisors: Mostafa A. El-Sayed, Adegboyega K. Oyelere, Bridgette A. Barry, L. Andrew Lyon, Zhong Lin WangGold nanoparticles exhibit a combination of physical, chemical, optical, and electronic properties unique from all other nanotechnologies. These structures can provide a highly multifunctional...
Novel Applications of Nanotechnology in Medicine and Green Energy
09 Jan 2012 | Contributor(s):: Hayden, Steven C.
Advisors: Mostafa A. El-Sayed, Uwe H. F. Bunz, Christine K. Payne, Ingeborg Schmidt-Krey, Laren M. TolbertThe development of techniques for colloidal nanoparticle synthesis has allowed scientists to fabricate materials that can manipulate light on a scale that is small even compared to the...