Microfluidic Cell Processing for Personalized and Regenerative Medicine
15 Sep 2021 | Contributor(s):: Stone, Nicholas Edwin
Advisors: Todd Sulchek, John McDonald, Alexander Alexeev, Ross Ethier, Budd TuckerCell processing lies at the heart of modern medicine. While in the past, the treatment of diseases such as cancer was based mostly on the cancer's tissue of origin and histological classification, today these...
Microfluidic Platforms for Multi-Protein Crosstalk and Its Application on Cell Sorting
08 Sep 2020 | Contributor(s):: Zhou, Fangyuan
Advisors: Cheng Zhu, Hang Lu, Susan N. Thomas, Todd Sulchek, Wilbur LamThis thesis describes the development of two platforms for cell receptor crosstalk study and their applications to several problems in cellular engineering. The first platform of an auto-alignment protein patterning approach...
High Throughput Multi-Modal Microfluidic System for Isolation of Blood Cells
20 Aug 2018 | Contributor(s):: Tasadduq, Bushra
Advisors: Todd Sulchek, Ali Fatih Sarioglu, Alexander Alexeev, Oliver Brand, Wilbur A. Lam, F. Levent DegertekinIn this study, we have developed a novel, multimodal microfluidic platform for cell sorting which utilizes size and adhesion as label-free biomarkers. The size biomarker is chosen as it...
Microfluidic Cell Separation Based on Cell Stiffness
07 Jan 2016 | Contributor(s):: Wang, Gonghao
Advisors: Todd Sulchek, Alexander Alexeev, Wilbur Lam, Hang Lu, Peter HeskethCell biophysical properties are a new class of biomarkers that can characterize cells into subgroups that indicate differences in phenotypes that may correlate with disease and cell state. Microfluidic biophysical cell...