Tags: Mechanobiology

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  1. Regulation of Platelet Integrin Mechanobiology by Talin

    15 Sep 2021 | Contributor(s):: Liao, Jiexi

    Advisors: Cheng Zhu, Shaun P Jackson, Brian G Petrich, Manu O Platt, Shuichi TakayamaPlatelets are exquisitely reactive to mechanical forces in disturbed blood flow caused by vessel branching, stenosis, and interventional medical devices, leading to life-threatening clots comprised of platelet...

  2. Force-Signaling Coupling at Single Focal Adhesions

    20 May 2020 | Contributor(s):: Zhou, Dennis Wei

    Advisors: Andres J Garcia, Cheng Zhu, Jennifer E Curtis, Andrew P Kowalczyk, Aranzazu del CampoIntegrin-mediated adhesion to extracellular matrices (ECM) provides forces and signals that direct cell processes central to tissue organization, homeostasis, and disease. Recent studies show an...

  3. Aortic Valve Mechanobiology- Role of Altered Hemodynamics in Mediating Aortic Valve Inflammation and Calcification

    07 Jun 2017 | Contributor(s):: Rathan, Swetha

    Advisors: Ajit P. Yoganathan, Hanjoong Jo, W. Robert Taylor, Julie A. Champion, Robert M. NeremCalcific aortic valve (AV) disease is a strong risk factor for cardiovascular related deaths and is a significant source of mortality worldwide, with the number of patients requiring AV surgery expected...