Design of High-Yielding Non-Enzymatic Dna and Rna Ligation Systems
10 Jun 2021 | Contributor(s):: Obianyor, Chiamaka
Advisors: Martha Grover, Nicholad Hud, Anant Paravastu, Corey Wilson, Mark StyczynskiThe demonstration of enzyme-free replication of nucleic acids, in particular RNA, will lend credence to the RNA world hypothesis which states that RNA was the first polymer on the prebiotic earth. One major...
Computational Analysis of the Structure and Noncovalent Interactions of Nucleic Acids and Their Analogs
10 Jun 2021 | Contributor(s):: Alenaizan, Asim
Advisors: Charles D Sherrill, Nicholas V Hud, Thomas M Orlando, Jesse G McDaniel, James C GumbartIn recent years, no event has been more consequential than the emergence of the Covid-19 pandemic. Covid-19 has disrupted the globe at an unprecedented scale and has caused profound changes to our...
Implementing Locked Nucleic Acids as a Bioinspired Colloidal Assembly and Disassembly Tool
22 May 2014 | Contributor(s):: Eze, Ngozi A.
Advisors: Valeria T. Milam, Kenneth Gall, Christopher J. Summers, Vladimir V. Tsukruk, Mark R. PrausnitzOligonucleotides are popular recognition-based biomaterials assembly and disassembly tools due to their specificity and ease of control. Their susceptibility to degradation by nucleases and...