Regulation of Platelet Integrin Mechanobiology by Talin
15 Sep 2021 | Contributor(s):: Liao, Jiexi
Advisors: Cheng Zhu, Shaun P Jackson, Brian G Petrich, Manu O Platt, Shuichi TakayamaPlatelets are exquisitely reactive to mechanical forces in disturbed blood flow caused by vessel branching, stenosis, and interventional medical devices, leading to life-threatening clots comprised of platelet...
Microfluidic Platforms for Multi-Protein Crosstalk and Its Application on Cell Sorting
08 Sep 2020 | Contributor(s):: Zhou, Fangyuan
Advisors: Cheng Zhu, Hang Lu, Susan N. Thomas, Todd Sulchek, Wilbur LamThis thesis describes the development of two platforms for cell receptor crosstalk study and their applications to several problems in cellular engineering. The first platform of an auto-alignment protein patterning approach...
Integrin Dynamics and Platelet Mechanosensing via Surface Receptors GPIba and Integrin aIIbb3
17 Aug 2017 | Contributor(s):: Chen, Yunfeng
Advisors: Cheng Zhu, Larry McIntire, Wilbur Lam, Renhao Li, Xiaoping DuIn hemostasis and thrombosis, platelet adhesion and signaling play key roles. Two platelet receptors, glycoprotein Iba (GPIba) and integrin aIIbb3, mediate the early and mid-stages of platelet adhesion in arterial...
Single-Molecue Study on GPIb-alpha and Von Willebrand Factor Mediated Platelet Adhesion and Signal Triggering
12 Jan 2015 | Contributor(s):: Ju, Lining
Advisors: Cheng Zhu, Jing-fei Dong, Jennifer E. Curtis, W. Robert Taylor, Larry V. McIntireThe binding between the 45 kDa N-terminal domain of the a subunit of the GPIb-IX-V complex (GPIbaN) on the platelet membrane and the A1 domain of von Willebrand factor (VWF-A1), a multimeric protein...